Specific IgM and high concentrations of specific IgG were
detected in 37 sera from 27 children with erythema infectiosum.
在27名患有感染性紅斑的兒童的37份血清中檢測到特異性IgM和高濃度的特異性IgG。
A total of 56 samples of serum from 32 patients with a clinical diagnosis of
human parvovirus B19 infection were tested for specific immunoglobulin G (IgG) and M (IgM) antibodies
檢測了來自32名臨床診斷為人細小病毒B19感染的患者的56份血清樣本的特異性免疫球蛋白G(IgG)和M(IgM)抗體
Specific IgM antibodies were detected in 94 % specimens collected 1 week after the onset
of illness and could be detected for up to 2 months.
在疾病發作後1週收集的94%標本中檢測到特異性IgM抗體,並且可以檢測長達2個月。
On the other hand, specific IgG antibodies were detected in 85 % patients
from whom acute- and convalescent-phase serum samples were collected.
另一方面,在收集急性期和恢復期血清樣品的85%患者中檢測到特異性IgG抗體。
小結1:
感染患者檢測出特異性IgM和高濃度的特異性IgG,這代表對抗病毒的是IgM和IgG。
B19 virus-infected persons during the acute phase of infection
had detectable IL-1β (20%), IL-2 (6%), IL-6 (26%), IL10 (4%), TNF-α (49%) and IFN-γ (67%).
感染急性期B19病毒感染者可檢測到IL-1β(20%),IL-2(6%),IL-6(26%),IL-10(4%),TNF-α(49%) 和IFN-γ(67%)。
Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the
large Parvoviridae family, are human pathogens responsible for a variety of diseases.
細小病毒B19(B19V)和人類博卡病毒1(HBoV1)是大型細小病毒科的成員,是導致各種疾病的人類病原體。
The levels and response kinetics of B19V-specific IgG subclasses to the VP1 and VP2 proteins
have also been elucidated (1088). For both antigens, the predominant
IgG subclass at all times is IgG1, whereas IgG2 levels remain very low and IgG3
is associated with the acute phase of infection.
IgG3與感染的急性期相關。
IFN-γ可以產生IgG2a、IgG3【呼應上方的IFN-γ(67%)】
IgA通過刺激巨噬細胞系的腫瘤壞死因子-α(TNF-α)產生【呼應上方的TNF-α(49%)】
鋅和維生素A缺乏與IgA產生較低有關。
補充維生素C提高了IgA血液中的濃度
能提高IFN-γ的元素:鋅、硒、錳、維生素C、高劑量維生素E
IL-4 promotes IgM maturation and increases surface IgM expression
IL-4促進IgM成熟並增加表面IgM表達
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456092/
Surface IgM (sIgM) was increased up to 10 times on human tonsillar B cells activated with IL-4.
在用IL-4激活的人扁桃體B細胞上,表面IgM(sIgM)增加至10倍。
能提高IL-4的元素:鋅、維生素A
小結2:
由以上可知,鋅、維生素A可以增加IgM也可以增加IgA促進TNF-α產生;
而鋅、維生素C可以增加IFN-γ→增加IgG3
總結以上:
建議一天一粒男性/女性善存補充鋅、維它命A、C+500毫克維它命C【https://zh-tw.ecaf(的相反)book.com/easydacom/】治療蘋果病(傳染性紅斑)
由於鋅、維它命A一天無法攝取太多,善存的鋅及維它命A劑量又很高,所以只能一天一粒(瓶裝標示也是一天一粒);不過維它命C比較可以攝取量大一點,所以除了善存本身的120毫克之外,建議再另外加500毫克。
含維生素A高的食物:胡蘿蔔、甜椒、鴨蛋黃、鵝蛋黃、枸杞、綠花椰菜、綠茶